Premature ovarian failure

Premature ovarian failure is a term that refers to the breakdown of the ovaries before they reach their full damage.

The cessation of menses before the age of 40 is known as premature ovarian failure. Premature ovarian failure can be caused by hereditary factors, autoimmune illnesses, or radiation therapy, chemotherapy, surgery, toxins, or other unknown factors that destroy the ovaries. Luteal phase problems are characterised by anomalies in the function of the corpus luteum, as well as insufficient progesterone synthesis.

Another possible cause is that despite normal synthesis, progesterone has insufficient influence on the endometrium.

The ovulation problems, which we have already described, constitute the next group of infertility causes:

  • The hypogonadotropic hypogonadism is the first type.
  • Polycystic ovarian syndrome, or PCOS for short, is a type two ovulation condition.
  • Hypogonadotropic hypogonadism is a type three ovulation condition.

Pelvic, tubal, and uterine problems are the fourth group of causes causing infertility in women.

Physical abnormalities of the female reproductive system, primarily as a result of disease or congenital disorders, are among the reasons of infertility. Damage to the cervix, uterus, fallopian tubes, and ovaries can sometimes be irreversible, making conception and pregnancy impossible. When an ovum is fertilised and implants outside the uterus, it is known as an ectopic pregnancy. Ectopic pregnancy has progressively increased over the previous two decades as a result of the frequency of sexually transmitted infections and, less commonly, the use of intrauterine contraceptive devices.

Premature Ovarian Failure

The presence of tiny implants of endometrial tissue and stroma abnormally implanted in tissue outside the individual cavity is classified as endometriosis.

Endometrial tissue that has been displaced can implant anywhere in the abdominal cavity and yet respond to hormones. When menstruation begins, endometriosis irritates the surrounding tissue, resulting in adhesions and scar tissue on the pelvic. Tubal factors for infertility are caused by injury or obstruction of the fallopian tubes, and they are a primary cause of infertility in up to 25% of women. Tubal factors that cause Endometriosis, pelvic inflammatory disease, and sexually transmitted illnesses can all lead to infertility.

An abnormal cervical mucus is another possible reason of infertility in this situation. The cervical mucus secreted fluctuates during a regular menstrual cycle and is predominantly influenced by oestrogen, with aberrant cervical mucus production. It can make it difficult for sperm to get past the cervix. About 10% of infertility is due to uterine abnormalities, with two of them being congenital defects.

Uterine leiomyomas, commonly known as uterine fibroid, and intrauterine adhesions, or Asherman’s Syndrome, are examples of anatomical anomalies. Mullerian malformations can cause uterine abnormalities like septate uterus, among other things.

Finally, unexplained infertility is described as the inability to conceive without a known cause, which affects up to 10% of infertile couples. Idiopathic infertility is the term for this type of infertility. It’s vital to remember that male variables, which are also mentioned here, play a part in infertility.

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