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Molecular Explanation for Age-Related Fertility

Molecular Explanation for Age-Related Fertility

As for the concept, the research and the studies were gone throng longer as the scientists of the National Institutes of Health who had supported the new theory as on why a woman's fertility condition declines earlier which is in her mid-30s. which them to has suggested a certain approach that might help the process to be slower, which is enhancing and prolonging fertility condition.

Normally, in a woman, the health and the number of eggs cells will determine the ability to get conceive and maintain a pregnancy in which it's linked with basically. Before once a baby girl is born, in her ovaries which contain a lifetime supply of egg cells which are too known as primordial follicle oocytes, which get more mature. As she gets ages up to her when she enters her late 30s, the number of oocytes gets decreases and fertility also slowly gets into dips precipitously. Also, once she reaches her early 50s, the process where her original ovarian supply of about 1 million cells drops virtually to zero at the time.

Also, while only a smaller number of oocytes of about 500 among all, which are released through the process of ovulation during the woman's regular menstruation life. The other remaining 99.9 percent of cells ar get eliminated normally by the process called cellular suicide in a woman's body, which is a general process as it prevents the spread or inheritance of damaged cells.

Also after research and studies, the scientists suspect that most aging oocytes self-destruct because they have accumulated or collected the dangerous type of DNA damage which is known as double-stranded breaks. As per studies, the older oocytes have more of their damaged ones than do younger ones. The studies were also found that older oocytes are less able to get in a fix with the DNA breaks due to their dwindling supply of repair molecules.

The research team's findings stemmed from their initial focus on BRCA1, a DNA repair gene that has been closely studied for nearly 20 years because defective versions of it dramatically increase a woman's risk of breast cancer.

Using mice bred to lack the BRCA1 gene, the NICHD-supported scientists confirmed that a healthy version of BRCA1 is vital to reproductive health. BRCA1-deficient mice were less fertile, had fewer oocytes, and had more double-stranded DNA breaks in their remaining oocytes than did normal mice.

Abnormal BRCA1 appears to cause the same problems in humans the team's studies suggest that if a woman's oocytes contain mutant versions of BRCA1, she will exhaust her ovarian supply sooner than women whose oocytes carry the healthy version of BRCA1.

Also, the studies have proved and termed in their findings that their actual ability of oocytes which get completely damaged and which to repair double-stranded DNA breaks the process which is connected internally with ovarian aging of the woman's and their extension which raises the fertility problems. In general, the scientists suggest the techniques which to bolster DNA repair systems in the ovaries might lead to treatments that can improve or prolong fertility.


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